I think it makes a huge difference on the type of card or autograph collecting you do.
Agreed. I still collect the odd auto card, but not the overpriced chase cards. You can occasionally grab up great looking in-person card autos (on eBay) on the cheap.

Old posters and photos rank high with me as well.

I just bought some almost 40 year-old hoops photos, that I thought I'd never find. Incredibly rare.

Also, Dr. J. game items are...
a) pretty spendy
b) often questionable

This sort of limits going gamer crazy.

Obviously, gamers are at the top of the popularity list, but one can still find unique and impressive items that fall into other memorabilia categories, IMO.