Former World Series MVP Manny Ramirez has been arrested over a domestic incident ... TMZ has learned.

Witnesses tell TMZ Ramirez was taken out of his Weston, Florida home at around 7 PM ET in handcuffs. We're told Ramirez' wife was in the house. Two witnesses tell TMZ Ramirez and his wife were involved in an altercation.

Ramirez' wife, Juliana, left the house shortly after Ramirez was taken away in the back of a police car.

He is currently in custody.

Story developing ....